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目的 通过系列体感诱发电位检查了解低分子肝素 (速避凝 )在急性脑梗死治疗中的疗效。方法 对 37例急性脑梗死患者在治疗前 ,治疗后 1周内 ,2周内 ,3周内共 4次作了经正中神经刺激短潜伏期体感诱发电位检查 ,记录了N2 0波的潜伏期和波幅 ,并对其中的 2 3例速避凝治疗者及 14例对照者进行对比研究。结果 脑梗死侧N2 0波的波幅在发病后 48h内已有明显降低 ,而潜伏期仅在 3周时稍有延长 ,且无显著统计学意义。速避凝治疗后 ,降低的N2 0波波幅有显著改善 ,而对照组则无变化。结论 速避凝治疗急性脑梗死改善了缺血半卵圆区微循环 ,保护了缺血后的脑功能 ,限制了梗死灶的扩大。我们认为体感诱发电位可以用来对治疗缺血性卒中的药物进行疗效评估。
Objective To understand the effect of low molecular weight heparin (fast avoidance) in the treatment of acute cerebral infarction by using a series of somatosensory evoked potentials. Methods 37 patients with acute cerebral infarction before treatment, 1 week after treatment, 2 weeks, 3 weeks were made a total of 4 times by the median nerve stimulation of short latency somatosensory evoked potentials were recorded N2 0 wave latency and amplitude , And among them 23 cases of rapid avoidance coagulation therapy and 14 cases of control were compared. Results The amplitude of N2 0 wave on cerebral infarction side had a significant decrease within 48 hours after onset, while the latency period was only slightly prolonged at 3 weeks, with no significant statistical significance. After the rapid contra-coagulation treatment, the amplitude of decreased N2 0 wave was significantly improved, while the control group had no change. Conclusion ATRA treatment of acute cerebral infarction can improve microcirculation of ischemic hemizygous area, protect the brain function after ischemia and limit the expansion of infarction. We think somatosensory evoked potentials can be used to assess the efficacy of drugs used to treat ischemic stroke.