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人体被乙型肝炎病毒（HBV）感染后发病主要与免疫损害有关，由细胞毒T细胞介导的肝细胞溶解在HBV的清除过程中起着重要作用，T细胞与靶细胞相互作用过程中既要识别HBV抗原，同时又要识别人白细胞1类抗原（HLA－Ia）。已有报道HLA－Ia的表达与肝脏病变活动和HBV的清除有关[1-4]
After the human body is infected by hepatitis B virus (HBV), the pathogenesis is mainly related to immune damage. The hepatocyte lysis mediated by cytotoxic T cells plays an important role in the clearance of HBV. During the interaction between T cells and target cells, To identify HBV antigens, but also to identify human leukocyte antigen 1 (HLA-Ia). It has been reported that the expression of HLA-Ia is associated with liver lesions and HBV clearance [1-4]