论文部分内容阅读
目的 :研究乳腺腺病与乳腺癌发生的关系。方法 :应用图象分析仪对 4 9例乳腺腺病、4 1例乳腺癌、6例正常乳腺组织进行DNA测定及利用胶银染色法进行AgNOR检测。 结果 :a .Ⅱ级腺病 (伴异型增生 )及乳腺癌的AgNOR数目明显多于Ⅰ级腺病 (不伴异型增生 ) ,Ⅱ级腺病与乳腺癌AgNOR的数目有部分重叠 ,且其大小、形态及分布亦相似于乳腺癌。b .Ⅰ、Ⅱ级腺病及乳腺癌的DNA含量具有显著差异。与Ⅰ级腺病相比 ,Ⅱ级腺病DNA含量明显增加 ,且有异倍体细胞出现。结论 :AgNOR数目及DNA含量的检测 ,在Ⅰ、Ⅱ级腺病的判定及Ⅱ级腺病与乳腺癌关系的研究中具有重要意义。对AgNOR数目增多及DNA含量增加的腺病 ,应警惕其癌变的可能。
Objective: To study the relationship between breast adenosis and breast cancer. Methods :Analyzing the DNA of 49 cases of breast adenosis, 41 cases of breast cancer, and 6 cases of normal breast tissue with image analyzer and AgNOR detection by gel silver staining. RESULTS: The number of AgNORs in grade a grade II adenosis (associated with dysplasia) and breast cancer was significantly greater than grade I adenosis (without dysplasia). The grade II adenosis and breast cancer had a partial overlap in the number of AgNOR and its size. The morphology and distribution are also similar to breast cancer. b. Significant differences in DNA content of grade I and II adenopathy and breast cancer. Compared with grade I adenopathy, grade II adenosis has a significant increase in DNA content and anomalous cells appear. Conclusion: The detection of AgNOR number and DNA content is of great significance in the determination of grade I and II adenosis and the relationship between grade II adenosis and breast cancer. For adenopathies with an increased number of AgNORs and increased DNA content, one should be wary of the possibility of canceration.