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表面活性剂 laureth-9(聚氧乙烯基-9-月桂醚,1％w/v)有促进鼻粘膜吸收的作用,同时可引起粘膜不同程度的破坏,如糜烂、细胞分离、粘膜增厚、失去粘膜表面的纤毛等,它可作为粘膜组织学变化的指示剂。本实验的目的是研究鼻中隔分成的两侧鼻腔能否一侧作为实验组织,另一侧充当对照组织。给3组雄性 Wistar 大鼠右鼻腔分别灌注含1％ laureth-9的磷酸缓冲液100,50,20μl,于5,20,60min 后处死动物做组织学切片。鼠鼻腔从前向后可分成5个区,Ⅱ区位于上切牙根与切嵴之间,Ⅲ区位于切嵴与第2腭嵴之间。
Surfactant laureth-9 (polyoxyethylene-9-lauryl ether, 1% w / v) has the effect of promoting nasal mucosal absorption, and can cause different degrees of mucosal damage such as erosion, cell separation, mucosal thickening, Loss of mucosal surface of the cilia, it can be used as an indicator of mucosal histological changes. The purpose of this experiment is to study the nasal septum can be divided into both sides of the nasal cavity can be used as experimental tissue on the other side as a control tissue. The right nasal cavity of three groups of male Wistar rats were perfused with 100, 50 and 20μl phosphate buffer containing 1% laureth-9, and the animals were sacrificed at 5, 20 and 60 minutes later for histological sections. The rat nasal cavity can be divided into 5 zones from anterior to posterior, Zone II is located between the incisor root and incision crest, Zone III is located between the incision crest and the second palatal crest.