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目的:研究阻塞性睡眠呼吸暂停综合征与高血压的临床关系及相关机制。方法:将258例鼾症患者分为三组:单纯鼾症对照组(N组)、单纯OSAHS组(O组)、OSAHS合并高血压组(O+H组)。对三组患者进行临床基础资料收集,ESS问卷调查及EP评分,多导睡眠监测及血压测定。结果:三组鼾症患者之间年龄、性别、吸烟、饮酒差异无统计学意义(P>0.05),OSAHS组及OSAHS+HT组体重指数及颈围明显高于单纯鼾症组,差异有统计学意义(P<0.05);与单纯鼾症组比较,OSAHS组及OSAHS+HT组的EP评分、AHI、LaSO2(%)、MSaO2、Ts90%差异明显有统计学意义(P<0.05);与对照组相比OSAHS组及OSAHS+HT组睡眠前后收缩压和舒张压升高,差异有统计学意义(P<0.05)。结论:阻塞性睡眠呼吸暂停综合征与高血压关系密切,慢性间歇缺氧是引起高血压的核心机制。
Objective: To study the clinical relationship between obstructive sleep apnea syndrome and hypertension and related mechanisms. Methods: 258 patients with snoring were divided into three groups: simple snore control group (N group), simple OSAHS group (O group) and OSAHS combined with hypertension group (O + H group). Three groups of patients were collected based on clinical data, ESS questionnaire and EP score, polysomnography and blood pressure monitoring. Results: There were no significant differences in age, sex, smoking, alcohol consumption between the three groups of snoring patients (P> 0.05). The body mass index and neck circumference in OSAHS group and OSAHS + HT group were significantly higher than those in simple snoring group (P0.05). Compared with simple snoring group, the scores of EP, AHI, LaSO2 (%), MSaO2 and Ts90% of OSAHS group and OSAHS + HT group were significantly different (P <0.05) Compared with OSAHS group and OSAHS + HT group, the systolic and diastolic blood pressure in the control group before sleep increased significantly (P <0.05). Conclusion: Obstructive sleep apnea syndrome is closely related to hypertension. Chronic intermittent hypoxia is the core mechanism of hypertension.