最近对因子Ⅷ和因子Ⅸ浓缩制剂引起的非甲非乙型肝炎极为关注,而人体正常免疫球蛋白(HNIg)常被认为不是病毒性肝炎感染的媒介物,因为在分级分离时以及免疫球蛋白中抗体的中和作用常使病毒丧失或灭活。对用于制备球蛋白的血浆已有敏感方法检测HBsAg,但对非甲非乙型肝炎尚无常规筛选方法。 Recently, there has been a great deal of concern for non-A, non-B hepatitis caused by factor VIII and factor IX concentration preparations, whereas human normal immunoglobulin (HNIg) is often not considered as a vehicle for viral hepatitis infection because, at fractionation, immunoglobulins The neutralizing effect of neutralizing antibodies often causes the virus to be lost or inactivated. There are already sensitive methods for the detection of HBsAg in plasma for the preparation of globulin, but no routine screening for non-A, non-B hepatitis.