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目的：通过整体动物实验和离体海马脑片实验，研究丹参合剂的抗脑缺氧作用。方法：观察密闭三角烧瓶中小白鼠缺氧存活时间；观察大鼠离体海马脑片缺氧过程中缺氧损伤电位（ＨＩＰ）的出现率及缺氧后诱发顺向群峰电位（ＯＰＳ）的恢复率和恢复程度。结果：小白鼠缺氧存活时间（ｍｉｎ），用药组（３３．１６±６．８７）较正常对照组（２１．１±３．９７）显著延长（Ｐ＜０．０１）；用药组ＯＰＳ恢复率７１．４％、恢复程度９２．４±５３．２％、ＨＩＰ发生率１４．３％，对照组ＯＰＳ恢复率２０％、恢复程度３０．２±３６．６％、ＨＩＰ发生率８０％，组间３项指标比较，差异均有显著性（Ｐ＜０．０５）。结论：实验用丹参合剂有明显的抗脑缺氧作用，其作用机制可能与丹参降低神经元的兴奋性，减少能耗，从而保护脑细胞有关。
OBJECTIVE: To study the anti-brain-anoxic effects of Dan-Shen mixture through the whole animal experiment and the isolated hippocampal slices. METHODS: The hypoxic survival time of mice in a sealed conical flask was observed; the occurrence of hypoxic injury potential (HIP) and the recovery of hypoxic-induced concomitant group peak (OPS) after hypoxia were observed in isolated rat hippocampal slices. Rate and degree of recovery. Results: Hypoxic survival time (min) in mice was significantly longer in the drug group (33.16±6.87) than in the normal control group (21.1±3.97) (P<0.01); OPS recovery in the drug group The rate was 71.4%, the degree of recovery was 92.4±53.2%, and the HIP incidence was 14.3%. In the control group, the recovery rate of OPS was 20%, the degree of recovery was 30.2±36.6%, and the incidence of HIP was 80%. There were significant differences between the three groups (P<0.05). Conclusion: The experimental Danshen mixture has obvious anti-cerebral anoxia effect. Its mechanism of action may be related to Salvia miltiorrhiza reducing neuronal excitability, reducing energy consumption, and thus protecting brain cells.