论文部分内容阅读
目的:探讨患者基础FSH/LH比值及控制性超促排卵(COH)时降调后hCG注射日血清LH水平对IVF-ET结局的影响及与COH各参数的关系。方法:回顾性分析首次进行IVF/ICSI-ET助孕、应用GnRH-a长方案降调节的不孕妇女,共427个周期。结果:ROC曲线显示FSH/LH比值与IVF-ET临床妊娠率无明显相关性;FSH/LH≥2与FSH/LH<2组间虽然临床妊娠率无差异,但FSH/LH≥2组Gn用量增加,获卵数少,优质胚胎数少,存在统计学差异(P<0.05)。hCG注射日血清LH≥0.65IU/L者妊娠率(55.8%)明显高于LH<0.65IU/L者(24.6%)。结论:基础FSH/LH比值增高能较早反映卵巢储备功能并指导超排方案及Gn用量;降调节后卵泡晚期(hCG注射日)的LH水平过低(<0.65IU/L),将会导致临床妊娠率下降。
OBJECTIVE: To investigate the effect of serum FSH / LH ratio on the outcome of IVF-ET and its relationship with the parameters of COH on the basis of the baseline FSH / LH ratio and the controlled ovarian hyperstimulation (COH) after hCG injection. Methods: A retrospective analysis of IVF / ICSI-ET-assisted pregnancy, application of GnRH-a regimen of infertile women with a total reduction of 427 cycles. Results: The ROC curve showed no significant correlation between the FSH / LH ratio and clinical pregnancy rate of IVF-ET. Although there was no difference in clinical pregnancy rates between FSH / LH≥2 and FSH / LH <2 groups, the Gn dosage of FSH / LH≥2 group Increased, less oocytes, lower quality embryos, there is a statistically significant difference (P <0.05). The pregnancy rate (55.8%) at LH≥0.65 IU / L on hCG injection was significantly higher than that of LH <0.65 IU / L (24.6%). CONCLUSIONS: The increased basal FSH / LH ratio can reflect the ovarian reserve function and guide the superovulation regimen and the Gn dosage earlier. Low LH level (<0.65IU / L) in the late follicle phase (hCG injection day) will lead to Clinical pregnancy rate decreased.