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[目的]探讨依地酸钠钙(CaNa2EDTA)治疗儿童慢性铅中毒的疗效及其安全性。[方法]对医院2006—2008年收治的60名中重度铅中毒儿童患者用CaNa2EDTA静脉滴注进行驱铅治疗,比较治疗前后的血铅变化,并观察其不良反应和副作用。[结果]60例中重度铅中毒患儿中,血铅平均浓度≥700μg/L者9例,450～700μg/L者29例,250～449μg/L者22例。治疗前血铅平均浓度分别为(881.76±141.03)、(545.47±51.54)、(389.07±39.49)μg/L。予以1个疗程CaNa2EDTA治疗后明显下降,血铅平均浓度分别为(585.78±115.17)、(356.97±27.3)、(213.23±37.09)μg/L。治疗期间无1例出现不良反应,复查相关项目未见异常。[结论]采用CaNa2EDTA静脉滴注治疗儿童中重度铅中毒,疗效显著,用药较安全。
[Objective] To investigate the curative effect and safety of sodium edetate calcium (CaNa2EDTA) in children with chronic lead poisoning. [Methods] Sixty children with moderate-to-severe lead poisoning who were treated in hospital from 2006 to 2008 were treated with lead-in therapy by CaNa2EDTA intravenous drip. The changes of blood lead before and after treatment were compared and the adverse reactions and side effects were observed. [Results] Among the 60 children with moderate or severe lead poisoning, 9 were blood lead level average ≥700μg / L, 29 were from 450-700μg / L and 22 were from 250 to 449μg / L. Blood lead levels before treatment were (881.76 ± 141.03), (545.47 ± 51.54) and (389.07 ± 39.49) μg / L, respectively. After a course of treatment CaNa2EDTA treatment decreased significantly, the average blood lead levels were (585.78 ± 115.17), (356.97 ± 27.3), (213.23 ± 37.09) μg / L. No adverse reactions occurred during the treatment, no abnormalities were found in the related items. [Conclusion] CaNa2EDTA intravenous drip treatment of children with moderate to severe lead poisoning, a significant effect, medication more secure.