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目的 通过对妇女月经模式及血清基础卵泡刺激素变化的调查,寻找有助于预测卵巢功能变化的简便临床手段。方法 选择35～49岁未绝经女性289例,以每5岁分组,对比各组月经周期、经期及经量变化,并检测血清基础卵泡刺激素(basal follicle stimulating hormone,bFSH),进行相关性分析。结果 随年龄增加月经规律性下降;35～40岁组稳定性高,40～44岁组周期明显缩短,45～49岁组周期延长、长短不一及跃过者比例均最高且经期变化最大。经量变化各组比较,差异无统计学意义(P>0.05)。月经模式中现状规律与否、周期、经期与年龄和bFSH之间相关性具有统计学意义(P<0.05)。结论 45～49岁组月经稳定性下降,主要表现周期先缩短,随后逐渐延长。故临床上可以通过月经模式中月经规律与否结合月经周期及经期变化情况初步判断卵巢功能的降低;bFSH有助于进一步明确这一判断。
Objective To investigate the changes of women’s menstrual patterns and serum basic follicle stimulating hormone in order to find a simple and convenient clinical method to predict the changes of ovarian function. Methods A total of 289 non-menopausal women aged 35-49 years were selected and divided into 5-year-old groups. The changes of menstrual cycle, menstrual period and menstrual flow were compared with each other. Serum basal follicle stimulating hormone (bFSH) . The results showed that the menstrual regularity decreased with age. The stability was high in 35-40 years old group. The 40-44 years old group was significantly shortened. The 45-49 years old group had the most prolonged periods, the different lengths and the overcrowded persons with the highest menstrual changes. The amount of change in each group, the difference was not statistically significant (P> 0.05). Menstrual patterns in the law of the status quo, the cycle, menstrual and age and bFSH correlation was statistically significant (P <0.05). Conclusion The menstrual stability of 45-49-year-old group decreased, the main performance period shortened first, and then gradually extended. Therefore, clinical menstrual patterns can be menstruation or menstrual cycle with menstrual cycle and menstrual changes initially determine the reduction of ovarian function; bFSH help to further clarify this judgment.