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目的研究56例COPD急性加重期的危重患者气道局部瘦素(Leptin)水平,并根据预后分成存活组与死亡组进行对照分析。方法研究对象为因严重呼吸衰竭而作气管插管或切开的COPD急性加重期危重患者,用纤维支气管镜吸取气道分泌液作瘦素测定,测定方法采用放射免疫分析。结果COPD急性加重期患者死亡组气道局部瘦素水平显著高于存活组(P<0.001);而在存活组中,气道局部瘦素水平又随患者病情好转稳定而显著下降(P<0.01)。结论气道局部瘦素水平升高预示COPD病情严重,而在治疗过程中气道局部瘦素水平也可随病情的好转而显著降低。
Objective To study the airway local leptin level in 56 critically ill patients with exacerbation of COPD and to analyze the prognosis of the patients according to the prognosis. Methods The subjects were critically ill COPD patients who had been extubated or severed due to severe respiratory failure. Bronchoscopy was used to measure airway secretion for leptin determination. Radioimmunoassay was used for the determination. Results The local airway leptin level in the death group was significantly higher than that in the survivors group (P <0.001), while in the survival group, the airway local leptin levels decreased significantly with the stable and stable patients (P <0.01) ). Conclusions Elevated airway leptin indicates the severity of COPD. Local airway leptin levels may also decrease with the improvement of the disease during the course of treatment.