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血管紧张素Ⅰ(简称ATⅠ)是体内已知的效力最强的加压物质。测定人体血浆中ATⅠ的浓度,对高血压的诊断、分型,指导治疗,预后估价以及发病原理的研究都有一定意义。此外、对内分泌疾病、泌尿系统疾病、计划生育、肾肿瘤、肾移植等的诊断和研究,也都有应用价值。上海市高血压研究所的革命科技人员顶着“四人帮”对科研工作的破坏和干扰,从1972年底开始对ATⅠ进行了研究。他们以毛主席的哲学思想为指导,经过近三年的努力,终于成功地获得了高滴度、高亲和力的抗ATⅠ血清。接着他们在南京军区总医院生化科的协作下,于1976年底建立了血浆中ATⅠ直接放射免疫测定法,最小检量为3.6±1.6微微克,达到国际先进水平。还建立了速尿和低钠(20毫当量/天)的激发试验,为评价肾素-血管紧张素系统的反应性提供了手段。同时通过对中国人血浆中ATⅠ的测定,获得了正常值(26±11微微克/毫升血浆)。近一年来,他们又开展了ATⅠ临床应用方面的
Angiotensin Ⅰ (referred to as AT Ⅰ) is the strongest known in the body of pressurized substances. Determination of human plasma AT Ⅰ concentration of hypertension diagnosis, classification, guiding treatment, prognosis and pathogenesis of the study have a certain significance. In addition, endocrine diseases, urological diseases, family planning, kidney cancer, kidney transplantation and other diagnosis and research, but also have application value. The revolutionary scientific and technological personnel of Shanghai Institute of Hypertension wore the destruction and disruption of scientific research carried out by the “gang of four”. From the end of 1972, ATⅠ was studied. Guided by Chairman Mao’s philosophical thinking, after nearly three years of hard work, they finally succeeded in obtaining high titers and high affinity anti-ATⅠ sera. Then, in collaboration with the Biochemistry Division of Nanjing Military Region General Hospital, they set up direct radioimmunoassay in plasma at the end of 1976, with a minimum of 3.6 ± 1.6 picogram, reaching the international advanced level. Furosemide and sodium hypoglycemic (20 meq / day) challenge tests were also established, providing a means of assessing the reactivity of the renin-angiotensin system. At the same time through the determination of AT I in Chinese plasma, normal (26 ± 11 pg / ml plasma) was obtained. In the past year, they have carried out the clinical application of AT Ⅰ