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目的:观察解毒化瘀汤联合西药治疗儿童皮肤型过敏性紫癜(HSP)血热妄行证的临床疗效,及对患儿血清炎症因子的影响。方法:选取72例皮肤型HSP血热妄行证患儿,随机分为中西医组和西医组各36例。2组均给予抗组胺药、钙剂和维生素C等药物治疗,西医组加用孟鲁司特,中西医组在西医组的用药基础上联合解毒化瘀汤治疗。2组均治疗4周。观察2组症状改善情况和皮损消退情况,以及2组治疗前后血清超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子(TNF)-α水平的变化。结果:中西医组治疗总有效率94.44%,西医组治疗总有效率77.78%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组血清hs-CRP和TNF-α水平均较治疗前下降(P<0.05,P<0.01);中西医组的血清hs-CRP及TNF-α水平均较西医组下降更明显(P<0.05)。结论:解毒化瘀汤联合西药治疗儿童皮肤型HSP血热妄行证,能有效改善患儿的症状,促进皮损消退及纠正炎症因子水平,疗效优于单纯使用西药治疗。
Objective: To observe the clinical efficacy of Jiedu Huayu Decoction combined with western medicine in treating children with skin-type Henoch-Schonlein purpura (HSP) and to investigate the effects of Jiedu Huayu decoction combined with Western medicine on serum inflammatory factors in children. Methods: Seventy-two children with skin-type HSP were randomly divided into two groups (36 cases in each group). 2 groups were given antihistamines, calcium and vitamin C and other drugs, Western medicine group montelukast, Chinese and Western medicine group in the Western medicine group on the basis of medication combined detoxification Huayu Tang treatment. Two groups were treated for 4 weeks. The improvement of symptoms and the regression of skin lesions were observed. The changes of serum hs-CRP and TNF-α levels were also observed before and after treatment. Results: The total effective rate was 94.44% in the Western medicine group and 77.78% in the Western medicine group. The difference between the two groups was statistically significant (P <0.05). After treatment, the levels of serum hs-CRP and TNF-α in two groups were significantly lower than those before treatment (P <0.05, P <0.01); the levels of serum hs-CRP and TNF- P <0.05). Conclusion: Detoxification Huayu Decoction combined with western medicine treatment of children with skin-type HSP hemorrhagic fever syndrome, can effectively improve children’s symptoms, promote skin lesions subside and correct the level of inflammatory cytokines, the effect is better than the simple use of Western medicine.