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本文论述吐温-丙二醇赋形剂对氢化可的松在小鼠皮肤上透皮速率的影响,采用小剂量(有限剂量)和超大剂量二种方法给药,并讨论其作用机理。小剂量的试验结果:如无表面活性剂(以下简称SAA)存在,氢化可的松的透皮速率随着丙二醇浓度(指赋形剂中的浓度,下同)的增加而下降;含有吐温20时,氢化可的松透皮速率随着丙二醇浓度的增加而加速,含其它吐温时,丙二醇浓度的改变无多大影响。丙二醇浓度为40%和60%时,SAA的
This article discusses the effects of Tween-Propylene Glycol excipient on transdermal rate of hydrocortisone on mouse skin. It is administered in small dose (limited dose) and very large dose, and its mechanism of action is discussed. Low-dose results: In the absence of surfactant (hereinafter referred to as SAA), hydrocortisone transdermal rate with the propylene glycol concentration (referring to the concentration of the vehicle, the same below) decreased; containing Tween At 20, the transdermal rate of hydrocortisone accelerated with increasing propylene glycol concentration, with little change in the concentration of propylene glycol when other tweens were included. Propylene glycol concentrations of 40% and 60% when SAA