目的评价９９ｍＴｃ羟基亚甲基二膦酸（ＭＤＰ）乳腺显像对乳腺癌的诊断价值。方法对６５例乳腺肿块患者进行乳腺和骨显像，取前位、左侧位、右侧位。病人均经手术和病理检查证实。结果９９ｍＴｃＭＤＰ诊断乳腺癌的灵敏度为９３３％，特异性８２９％，诊断正确率８７７％，假阴性率６７％，假阳性率１７１％，乳腺肿块与健侧相应部位ＲＯＩ的放射性比值，乳腺癌组为２５１±０３３，良性病变组为１９１±０２０，Ｐ＜０００１。３０例乳腺癌骨显像中７例发现有转移灶。结论９９ｍＴｃＭＤＰ显像对乳腺癌的诊断、良恶性乳腺肿块的鉴别及有无早期骨转移灶的判断很有价值。 Objective To evaluate the diagnostic value of 99mTc-hydroxymethylene diphosphonic acid (MDP) breast imaging in breast cancer. Methods Breast and bone imaging were performed in 65 patients with breast lumps, and the anterior, left and right flaps were taken. Patients were confirmed by surgery and pathology. Results The sensitivity of 99mTcMDP in diagnosis of breast cancer was 933%, specificity was 829%, diagnosis accuracy was 877%, false negative rate was 6.7%, false positive rate was 171%, breast mass and healthy The radioactivity ratio of ROI in the corresponding side was 251 ± 033 in breast cancer group and 191 ± 020 in benign lesion group, P <0001. Among the 30 cases of breast cancer bone imaging, 7 cases were found Metastases. Conclusion 99mTc MDP imaging diagnosis of breast cancer, benign and malignant breast tumor identification and early diagnosis of bone metastases are valuable.