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目的观察康复新液雾化吸入对急性放射性口腔黏膜炎的作用。方法将50例头颈部恶性肿瘤患者，随机分为预防用药组和对照组(25例)。预防用药组用康复新液10ml加生理盐水10ml雾化吸入，1次/d，至放疗结束；对照组用生理盐水20ml，4次/d漱口，出现吞咽疼痛时餐前服2%利多卡因15ml。两组患者均采用直线加速器放疗。结果两组急性放射性口腔黏膜炎发生率差异无统计学意义(>0.05)。预防用药组口腔溃疡Ⅰ-Ⅱ级20例，Ⅲ-Ⅳ级1例(4%)；对照组Ⅰ-Ⅱ级15例，Ⅲ-Ⅳ级10例(40%)，对照组中重度口腔溃疡发生率显著高于预防用药组(<0.05)。两组急性黏膜反应出现的时间比较，具有显著性差异(0.05). Prevention of 20 cases of treatment group oral ulcer I~I , II ~IV in 1 case (4%);control group I and I in 15 cases, I I~IV in 10 cases (40%), the control group in severe oral ulcer occur ed was significantly higher than that of preventive medication group ( <0.05). In the two groups, there were significant dif erences in the time of acute mucosal reaction ( <0.05), which indicated that the prevention of the treatment group was delayed in the control group.Conclusion Rehabilitation new atomization inhalation can reduce acute toxicity grading of inflammation of radioactive oral cavity mucous membrane,al eviate the acute radioactive pain,acute mucosa reaction time delay,whole process helps to smooth completion of radiotherapy.