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目的分析血清抵抗素、脂联素及IGF-1水平与糖尿病肾病的相关性。方法收集该院糖尿病肾病患者109例作为A组,单纯糖尿病患者109例作为B组。同期收集我院体检健康的正常志愿者109例作为对照组。抽取所有患者及健康志愿者晨起空腹肘静脉血,采用酶联免疫吸附试验检测其血清抵抗素、脂联素及胰岛素样生长因子-1(IGF-1),比较分析3组差异。结果所有患者血清抵抗素、脂联素及IGF-1水平均为对照组最低,B组次之,A组最高,差异均具有统计学意义(P<0.05)。结论血清抵抗素、脂联素及IGF-1水平与糖尿病肾病存在相关性,正常人群各项指标水平最低,随着糖尿病病情加重其检测值逐渐升高,而糖尿病肾病患者各项指标检测值最高。
Objective To analyze the correlation between serum resistin, adiponectin and IGF-1 and diabetic nephropathy. Methods A total of 109 patients with diabetic nephropathy in the hospital were enrolled as group A and 109 patients with simple diabetes as group B. In the same period, 109 normal volunteers who collected the physical examination in our hospital were taken as the control group. Fasting elbow venous blood was collected from all patients and healthy volunteers at the early morning. Serum resistin, adiponectin and insulin-like growth factor-1 (IGF-1) were detected by enzyme-linked immunosorbent assay (ELISA). Results The levels of serum resistin, adiponectin and IGF-1 in all patients were the lowest in the control group, followed by those in the B group, and the highest in the A group (all P <0.05). Conclusion The levels of serum resistin, adiponectin and IGF-1 are correlated with diabetic nephropathy. The indexes in normal population are the lowest. The detection value increases with the aggravation of diabetes mellitus, while the detection index of diabetic nephropathy patients is the highest .