目的　为探讨前列腺素 E1 对早期糖尿病肾病的治疗效果。方法　 80例 2型糖尿病肾病 ( 期 )患者随机分为治疗组 4 5例、对照组 35例。两组均采用西药对症处理 ,饮食控制 ,在此基础上治疗组给予前列腺素 E1 治疗 ,连续治疗观察 1个疗程 (2周 )。结果　本资料显示 ,治疗组的血液流变学、有关肾脏生化检查指标改善 ,均优于对照组 (P<0 .0 5或 P<0 .0 1)。结论　本资料表明通过改善肾小球微循环的药可以降低尿白蛋白 ,有效延缓或终止早期糖尿病肾病的发展 Objective To investigate the effect of prostaglandin E1 on early diabetic nephropathy. Methods Eighty patients with type 2 diabetic nephropathy (stage) were randomly divided into treatment group (45 cases) and control group (35 cases). Both groups were treated with western medicine symptomatic treatment, diet control, on this basis, the treatment group given prostaglandin E1 treatment, continuous treatment to observe a course of treatment (2 weeks). Results The data show that the treatment group, hemorheology, renal biochemical test indicators improved, were better than the control group (P <0.05 or P <0.01). Conclusion This data indicates that urinary albumin can be decreased by improving glomerular microcirculation and effectively delay or terminate the development of early diabetic nephropathy