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目的 :探讨羟基喜树碱 (HCPT)、依托泊苷 (VP16 )、5 氟尿嘧啶 (5 FU)联合方案治疗老年人晚期胃癌的疗效和毒副作用。方法 :比较HCPT +VP16 +CF + 5 FU(ELFH)方案与HCPT + 5 FU +VP16 (EFH)方案。结果 :ELFH组 42例有效率为 5 2 4%。EFH组 40例有效率为 42 5 % ,两组疗效比较差异无显著性。ELFH组毒副反应较EFH组发生率高 ,主要为骨髓抑制、恶心呕吐、口腔粘膜炎、腹泻等。结论 :老年人晚期胃癌以EFH方案更为理想
Objective: To investigate the curative effect and toxicity of hydroxycamptothecin (HCPT), etoposide (VP16) and 5-fluorouracil (5 FU) in elderly patients with advanced gastric cancer. Methods: HCPT + VP16 + CF + 5 FU (ELFH) protocol and HCPT + 5 FU + VP16 (EFH) protocol were compared. Results: The effective rate of 42 cases in ELFH group was 52.4%. The effective rate of 40 cases in EFH group was 42.5%, there was no significant difference between the two groups. The incidence of side effects in ELFH group was higher than that in EFH group, mainly including myelosuppression, nausea and vomiting, oral mucositis and diarrhea. Conclusion: The elderly patients with advanced gastric cancer with EFH program is more ideal