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有资料表明,高峰血药浓度与MIC的比值是衡量某一种氨基糖苷类抗生素疗效的重要指数。另据报告,在日剂量不变的情况下,减少每日给药次数可使氨基糖苷类的肾毒性降低,故可认为每日一次给药法能有效地提高氨基糖苷类的疗效并减低其毒副作用。作者研究了健康人对乙基西索米星(Netilmicin)和Teicoplanin的耐受性。试验将30名21～30岁的健康男性志愿者随机分为4组,分别给予乙基西索米星4.5mg/kg、Teicoplanin6mg/kg、乙基西索米星+Teicoplanin6mg/kg、乙基西索米星+Teicoplanin(两药剂量同上,注射于不同部位)、或安慰剂肌肉注射,每日1次(每天
Data show that the ratio of peak plasma concentration to MIC is a measure of the effectiveness of certain aminoglycoside antibiotics an important index. It has also been reported that in the case of a constant daily dose, the reduction in the number of daily dosing can reduce the nephrotoxicity of aminoglycosides, so that once daily administration can effectively improve the aminoglycoside efficacy and reduce its toxic side effect. The authors studied the tolerance of healthy people to Netilmicin and Teicoplanin. Thirty healthy male volunteers aged 21 to 30 years were randomly divided into 4 groups, each group received 4.5 mg / kg of ethyl sisomicin, 6 mg / kg of Teicoplanin, 6 mg / kg of ethyl sisomicin + Teicoplanin, Somicin + Teicoplanin (both doses as above, injected at different sites), or placebo intramuscular injection once daily (daily