自1950年以来在日本对痢疾的治疗,多使用氯霉素和四环素,由于广泛使用的結果,耐药菌株不断增长(1957年为5％,1958年为8—10％,1959—1960在10—20％,1961年为20—30％),1962年在6个城市的医院中由痢疾病人及带菌者共分离出6583株痢疾杆菌,其中91.24％对浓度为100微克/毫升的鏈霉素、氯霉素、四环素有耐药性。为了治疗这些对抗菌素有耐药性菌株所致的痢疾,曾分別使用了卡那霉案、粘菌素——甲基磺酸 Due to the widespread use of chloramphenicol and tetracycline in the treatment of dysentery in Japan since 1950, drug-resistant strains have been steadily increasing (5% in 1957, 8-10% in 1958, 10-59 at 1959-1960 -20% in 1961 and 20-30% in 1961). In 1962, 6583 strains of Shigella dysenteriae were isolated from dysentery patients and carriers in hospitals in 6 cities, of which 91.24% were susceptible to streptomycin at a concentration of 100 μg / ml , Chloramphenicol, tetracycline resistance. For the treatment of dysentery caused by antibiotic-resistant strains, kanamycin, colistin-methanesulfonate