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原发性胆汁性肝硬化的表现形式不一,可为症状性或无症状。本文对耶尔肝脏研究部1955～1979期间经临床、生化和组织学确诊的280例原发性胆汁性肝硬化的自然病史进行回顾性再分析,旨在探讨与存活期相关而最能估测预后的临床和组织学表现。其中症状组243例(87%),无症状组37例(13%)。两组平均随访时间(6.7和6.9年)、平均年龄(47.1和48.8岁)相仿,女性各占92%。结果:体检:黄疸、肝大、脾大、腹水、色素过度沉着和黄疣在症状组均较非症状组多见,尤以肝大最为常见。无症状病人肝大常为唯一体检异常。实验室检查:粒线体抗体检出率二组均为81%,滴定度超过1∶500者在症状组高达47%,非症状组仅占23%。血清碱性磷
The manifestations of primary biliary cirrhosis vary and may be symptomatic or asymptomatic. In this paper, we retrospectively reviewed 280 cases of primary natural history of biliary cirrhosis clinically, biochemically and histologically confirmed by Hyerl’s Department of Liver Research between 1955 and 1979 to explore the most probable Prognosis of clinical and histological manifestations. Among them, 243 cases (87%) were symptom group and 37 cases (13%) were asymptomatic group. The average follow-up time (6.7 and 6.9 years) in both groups was similar with mean age (47.1 and 48.8 years) and 92% in women. Results: Physical examination: jaundice, hepatomegaly, splenomegaly, ascites, hyperpigmentation and yellow warts were more common in symptom group than in non-symptom group, especially in the liver. Patients with asymptomatic liver is often the only physical examination abnormalities. Laboratory tests: The detection rate of mitochondrial antibodies was 81% in both groups. The titer of more than 1: 500 was 47% in the symptom group and only 23% in the non-symptomatic group. Serum alkaline phosphorus