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目的探讨肝素结合蛋白(HBP)联合白介素-8(IL-8)、降钙素原(PCT)水平检测诊断急性重症胰腺炎(SAP)继发感染的临床价值。方法选取SAP患者90例,根据诊断标准将所有患者中未继发感染的48例患者设为对照组,继发感染的42例患者设为观察组。对比分析两组的HBP、PCT、IL-8水平及其对SAP继发感染诊断的准确性。结果观察组的HBP、PCT、IL-8水平均明显高于对照组,差异具有统计学意义(P<0.05);联合检测的HBP、PCT、IL-8指标的准确性及敏感性均明显高于单一的指标或任意两项指标联合检测,差异具有统计学意义(P<0.05)。结论联合检测HBP+PCT+IL-8水平在临床诊断SAP的继发感染中准确性高,可为早期SAP的诊疗提供重要的依据。
Objective To investigate the clinical value of detecting heparin-binding protein (HBP) combined with interleukin-8 (IL-8) and procalcitonin (PCT) in the diagnosis of secondary infection of acute severe pancreatitis (SAP). Methods Totally 90 SAP patients were selected. According to the diagnostic criteria, 48 patients with no secondary infection in all patients were selected as the control group and 42 patients with secondary infection as the observation group. The levels of HBP, PCT and IL-8 were compared between the two groups and their diagnostic accuracy for secondary SAP infection. Results The levels of HBP, PCT and IL-8 in the observation group were significantly higher than those in the control group (P <0.05). The accuracy and sensitivity of the combined detection of HBP, PCT and IL-8 were significantly higher In a single index or any two indicators combined detection, the difference was statistically significant (P <0.05). Conclusion The combined detection of HBP + PCT + IL-8 in the diagnosis of secondary infection of SAP with high accuracy can provide an important basis for the diagnosis and treatment of SAP in the early stage.