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目的：了解创伤性脑损伤（ｔｒａｕｍａｔｉｃｂｒａｉｎｉｎｊｕｒｙ，ＴＢＩ）后脑组织Ｍｇ２＋含量的连续性变化并探讨其意义；方法：ＳＤ大鼠２８只随机分为假手术对照组（ｎ＝４）、损伤组（ｎ＝２４）。损伤组伤后１、４、２４、４８、７２、１６８ｈ处死，选用原子吸收分光光度法测定脑组织Ｍｇ２＋含量；结果：颅脑损伤后脑组织中Ｍｇ２＋含量在伤后即迅速下降，在２ｈ时达最低值，然后迅速回升，并超过损伤前水平，在７０ｈ时达到最大值，后缓慢下降，并逐渐接近伤前水平（Ｐ＜０．０１）；结论：（１）大鼠ＴＢＩ后脑组织中镁含量可出现持续约２０ｈ的降低，以损伤后２ｈ降低最显著，证实Ｍｇ２＋在ＴＢＩ继发性脑损害早期起重要作用。（２）ＴＢＩ后Ｍｇ２＋治疗“时机窗口”应控制在２４小时内，尽量超早期应用。
Objective: To investigate the continuity of Mg2 + content in brain tissue after traumatic brain injury (TBI) and to explore its significance.Methods: 28 SD rats were randomly divided into sham operation control group (n = 4), injury group (n = 24). At 1, 4, 24, 48, 72 and 168 h after injury, the injured group was sacrificed. The contents of Mg2 + in brain tissue were determined by atomic absorption spectrophotometry. Results: The content of Mg2 + (P <0.01) .Conclusion: (1) The contents of magnesium in brain tissue after TBI in rats were significantly lower than those before injury (P <0.01) The content can appear to reduce about 20h, to 2h after injury the most significant reduction, confirmed that Mg2 + plays an important role in early TBI secondary brain damage. (2) Mg2 + treatment after TBI “timing window” should be controlled within 24 hours, try to ultra-early application.