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两组大鼠先分别经小剂量CCl_4或半乳糖胺造成损伤,其SGPT升高为正常对照组的4倍左右;然后分为两组,分别皮下注射一次消炎痛和等量溶剂,24小时后,再交叉给予较大剂量的半乳糖胺和CCl_4再次造成损伤。结果表明,不论先后接受CCl_4和半乳糖胺的大鼠,还是先后接受半乳糖胺和CCl_4的大鼠,经消炎症处理组的SGPT和血清胆红素均显著低于未经消炎痛处理的对照组。提示消炎痛处理能使已经受损的大鼠肝脏对再次损伤产生明显的保护作用。
Two groups of rats were first caused by small dose of CCl_4 or galactosamine injury, the SGPT increased to about 4 times the normal control group; then divided into two groups, were injected subcutaneous indomethacin and an equal amount of solvent, 24 hours later , And then given a larger dose of galactosamine and CCl_4 again caused damage. The results showed that SGPT and serum bilirubin of the rats treated with anti-inflammatory were significantly lower than those of rats without CCI4 and galactosamine, or those receiving galactosamine and CCl4 successively group. It is suggested that indomethacin treatment can significantly damage the already damaged rat liver against re-injury.