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1 SF-1和DAX-1的发现和结构1.1 SF-1 SF-1又称为Ad4BP或NR5A1。LaLa等人于1992年在寻找与类固醇羟化酶基因(CYPs)的启动子元件相互作用的转录因子时发现了SF-1〔1〕。同时Morohashi利用寡核苷酸亲和柱结合牛肾上腺蛋白提取物分离纯化得到一种分子量为53×103的SF-1蛋白质,由于这个蛋白质能够
1 Discovery and structure of SF-1 and DAX-1 1.1 SF-1 SF-1 is also known as Ad4BP or NR5A1. LaLa et al. Found SF-1 [1] in 1992 when looking for transcription factors that interact with the promoter elements of steroid hydroxylase genes (CYPs). At the same time Morohashi using oligonucleotide affinity column with bovine adrenal protein extract isolated and purified to a molecular weight of 53 × 103 SF-1 protein, because the protein can