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术后早期采用小剂量白细胞介素－2（IL－2），2～3周后采用IL－2加卡介苗进行膀胱灌注防治膀胱肿瘤复发，并与单纯灌注卡介苗的患者进行对照，结果表明术后早期膀胱灌注IL－2，患者血中环磷酸腺苷（cAMP）、肿瘤坏死因子（TNF）含量升高；1年及1～4年总复发率降低，效果较单纯灌注卡介苗者优越。提示IL－2膀胱灌注可调节免疫功能，通过cAMP下调癌基因表达及诱导分化，防治肿瘤复发，是防治膀胱肿瘤复发的安全、有效的措施。
Early postoperative use of low-dose interleukin-2 (IL-2), 2 to 3 weeks after the use of IL-2 plus BCG bladder instillation of bladder cancer recurrence, and compared with the simple perfusion of BCG patients, the results showed that postoperative In the early stage of intravesical instillation of IL-2, the levels of cAMP and TNF in the blood increased. The overall relapse rate decreased in 1 year and 1 to 4 years, and the effect was better than that of BCG alone. It is suggested that IL-2 bladder infusion can regulate immune function, reduce the recurrence of bladder tumor by cAMP downregulating oncogene expression and inducing differentiation, which is a safe and effective measure to prevent recurrence of bladder tumor.