向Wistar大鼠脑内注射6羟多巴胺(6-OHDA)破坏一侧黑质,造成药物诱发的旋转动物模型。将同系大鼠肾上腺髓质植入模型鼠损伤侧尾状核部,2个月后观察行为改变,其中34％停止旋转,57％旋转次数明显减少。未经移植的损伤一侧脑对酪氨酸、多巴胺(DA_2)和胆碱的摄取明显增加,DA_2受体结合活性也明显增加,而胆碱能M受体和GABA_A受体结合活性明显下降,上述变化经肾上腺髓质移植后均恢复至正常水平。 Injection of 6-hydroxydopamine (6-OHDA) into the brain of Wistar rats disrupts one side of the substantia nigra and results in a drug-induced rotational animal model. The adrenal medulla of the same type rats were implanted into the caudate nucleus of the caudal caudal mucosa. Two months later, behavioral changes were observed. Among them, 34% stopped rotating and the number of 57% rotation decreased significantly. The brain of tympanic acid, dopamine (DA_2) and choline in the untreated lesion increased significantly, the binding activity of DA_2 receptor increased significantly, while the binding activity of cholinergic M receptor and GABA_A receptor decreased significantly, The above changes by the adrenal medulla were restored to normal levels.