检测１１４例糖尿病患者和１００例健康人血浆中的一氧化氮（ Ｐ Ｎ Ｏ）、维生素 Ｃ（ Ｐ Ｖ Ｃ）、维生素 Ｅ（ Ｐ Ｖ Ｅ）、β胡萝卜素（ Ｐβ Ｃ Ａ Ｒ）、过氧化脂质（ Ｐ Ｌ Ｐ Ｏ）含量及红细胞中的超氧化物歧化酶（ Ｅ Ｓ Ｏ Ｄ）、过氧化氢酶（ Ｅ Ｃ Ａ Ｔ）、谷胱甘肽过氧化物酶（ Ｅ Ｇ Ｓ Ｈ Ｐｘ）活性和过氧化脂质（ Ｅ Ｌ Ｐ Ｏ）含量以探讨与糖尿病的关系。结果表明，糖尿病组及Ⅰ型、Ⅱ型糖尿病组的 Ｐ Ｎ Ｏ、 Ｐ Ｌ Ｐ Ｏ、 Ｅ Ｌ Ｐ Ｏ 均显著高于对照组（ Ｐ＜ ００１）， Ｐ Ｖ Ｃ、 Ｐ Ｖ Ｅ、 Ｐβ Ｃ Ａ Ｒ、 Ｅ Ｓ Ｏ Ｄ、 Ｅ Ｃ Ａ Ｔ、 Ｅ Ｇ Ｓ Ｈ Ｐｘ 均显著低于对照组（ Ｐ＜ ００１）；并随着病程的延长而逐渐升高或降低。逐步回归分析结果提示患者病程与 Ｐ Ｎ Ｏ、 Ｐ Ｖ Ｃ、 Ｅ Ｓ Ｏ Ｄ、 Ｅ Ｇ Ｓ Ｈ Ｐｘ、 Ｅ Ｌ Ｐ Ｏ 值密切相关。认为糖尿病患者 Ｎ Ｏ 代谢异常，抗氧化、抗过氧化和抗脂质过氧化作用受损。 The plasma levels of nitric oxide (PN O), vitamin C (PV C), vitamin E (PV E) and β  carotene (P   β) in 114 patients with diabetes mellitus and 100 healthy people were detected. C A R), lipid peroxidation (P L P O) content and erythrocyte superoxide dismutase (E S D), catalase (E C A T), glutathione Peroxidase (E G S H Px) activity and lipid peroxide (E L P O) content to explore the relationship with diabetes. The results showed that the PN O, PL P O and EL P O in diabetic group and type Ⅰ and type Ⅱ diabetic patients were significantly higher than those in control group (P <001), PV C, P V E, PβC A R, ES O D, EC A T, EG S HPx were significantly lower than those in the control group (P <001) Extend and gradually increase or decrease. Stepwise regression analysis showed that the patient’s course of disease was closely related to PN O, PV C, ES O D, EG S HPx and EL P O. It is considered that patients with diabetes have abnormal N O metabolism and are impaired in their anti-oxidation, anti-peroxidation and anti-lipid peroxidation effects.