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目的探讨特布他林联合布地奈德雾化吸入治疗支气管哮喘(哮喘)的疗效及安全性。方法选取2012年12月—2013年12月成都市第三人民医院收治的哮喘患者120例,随机分为治疗组和对照组,各60例。对照组采用常规治疗,治疗组在常规治疗基础上给予特布他林布联合地奈德雾化吸入治疗。比较两组患者呼气流量峰值差值(△PEF),喘息、胸闷、咳嗽、哮鸣音缓解时间和住院时间,患者口咽感染、声嘶、口干、手指震颤例数。结果两组患者△PEF、喘息、咳嗽、哮鸣音缓解时间、住院时间比较,差异有统计学意义(P<0.05),两组患者胸闷缓解时间比较,差异无统计学意义(P>0.05)。两组患者口咽感染、口干、手指震颤例数比较,差异无统计学意义(P>0.05),两组患者声嘶例数比较,差异有统计学意义(P<0.05)。结论特布他林联合布地奈德雾化吸入治疗哮喘是安全、有效的。
Objective To investigate the efficacy and safety of terbutaline combined with budesonide inhalation in the treatment of bronchial asthma (asthma). Methods A total of 120 asthmatic patients admitted to the Third People ’s Hospital of Chengdu from December 2012 to December 2013 were randomly divided into treatment group and control group, with 60 cases in each group. The control group was treated by conventional therapy, and the treatment group was given terbutaline and desonex inhalation on the basis of routine treatment. The differences of peak expiratory flow (△ PEF), wheezing, chest tightness, cough, wheeze relief time and length of hospital stay, oropharyngeal infection, hoarseness, dry mouth and fingers tremor were compared between the two groups. Results The difference of △ PEF, wheezing, cough, wheeze relief time and length of hospital stay between the two groups was statistically significant (P <0.05). There was no significant difference between the two groups in the time of relieving chest tightness (P> 0.05) . There was no significant difference in the number of cases of oropharyngeal infection, dry mouth and finger tremor between the two groups (P> 0.05). The difference of hoarseness between the two groups was statistically significant (P <0.05). Conclusion Terbutaline combined with budesonide inhalation for asthma is safe and effective.