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目的:初步探讨葛根素注射液引起新西兰兔急性血管内溶血的剂量及出现溶血的时间。方法:200,160,80,40,20,0mg.kg-1各组动物分别耳缘静脉注射给予葛根素注射液4mL.kg-1,并于给药前、给药后5,20min,1,2,8,24,48,72h耳缘静脉采血,进行血清胆红素,血浆血红蛋白,血液红细胞计数、血红蛋白、红细胞容积的测定。结果:80,160,200mg.kg-1组家兔的游离血浆血红蛋白、血清胆红素给药后5min至8h显著升高,与对照组比较有明显差异(P<0.05)。结论:高剂量葛根素注射液可引起新西兰兔急性血管内溶血。
Objective: To investigate the dose and time of hemolysis of acute intrahepatic hemolysis caused by puerarin injection in New Zealand rabbits. Methods: 200, 160, 80, 40, 20, and 0 mg.kg-1 of each group were given 4mL.kg-1 puerarin injection by ear vein injection respectively. , 8,24,48,72 h ear vein blood collection, serum bilirubin, plasma hemoglobin, blood red blood cell count, hemoglobin, red blood cell volume determination. Results: Free plasma hemoglobin of 80, 160 and 200mg.kg-1 groups were significantly increased from 5min to 8h after administration of serum bilirubin, which was significantly different from the control group (P <0.05). Conclusion: High dose puerarin injection can cause acute intravascular hemolysis in New Zealand rabbits.