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目的探讨分析子宫颈黏液腺癌的病理诊断过程,以此为早期诊断提供临床依据,并降低漏诊几率。方法选取自2009年3月至2011年7月入住我院治疗的40例子宫颈黏液腺癌患者,采用回顾性方法 ,对其临床资料与诊断过程进行探讨分析,使用LABC法免疫组化,进行CEA与Ki-67表达检测。结果 40例子宫颈黏液腺癌患者中,直接有子宫颈活检确诊为子宫颈黏液腺癌25例;经子宫颈活检诊断为子宫颈原位腺癌5例,慢性子宫颈炎3例,后采用LEEP术均确诊为子宫颈浸润性黏液腺癌;诊断为腺癌1例,无法确定组织性类型,术后确诊为子宫颈黏液腺癌;漏诊6例,其中TCT漏诊2例,子宫颈活检漏诊4例。经LABC法染色显示,19例CEA表达阳性,Ki-67表达均升高(均>20%)。结论从细胞学与组织形态学出发,进行子宫颈黏液腺癌的诊断工作,可以减少误诊漏诊现象,便于医师及早做出准确诊断,并进行对症治疗。
Objective To investigate the pathological diagnosis of cervical mucinous adenocarcinoma and to provide a basis for early diagnosis and to reduce the risk of missed diagnosis. Methods Forty cases of cervical mucinous adenocarcinoma admitted to our hospital from March 2009 to July 2011 were retrospectively studied. The clinical data and diagnosis process were analyzed and analyzed by LABC immunohistochemistry. CEA and Ki-67 expression detection. Results Among the 40 cases of cervical mucinous adenocarcinoma, 25 cases of cervical mucinous adenocarcinoma were directly diagnosed by cervical biopsy. In cervical biopsy, 5 cases were diagnosed as adenocarcinoma of the cervix and 3 cases of chronic cervicitis. LEEP Were diagnosed as cervical invasive mucinous adenocarcinoma; diagnosis of adenocarcinoma in 1 case, can not determine the histological type, postoperative diagnosis of cervical mucinous adenocarcinoma; missed diagnosis in 6 cases, including TCT missed diagnosis in 2 cases, cervical biopsy missed diagnosis in 4 cases . The results of LABC staining showed that CEA was positive in 19 cases and the expression of Ki-67 was increased (all> 20%). Conclusion Based on cytology and histomorphology, the diagnosis of cervical mucinous adenocarcinoma can reduce the misdiagnosis and missed diagnosis, facilitate physicians to make accurate diagnosis as soon as possible and carry out symptomatic treatment.