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目的利用猴局部脑缺血模型探讨CT灌注成像在超急性缺血性脑梗塞研究中的意义。方法采恒河猴静脉血制作自体白色血栓,经DSA手术导入至一侧大脑中动脉M1段分支,分别于栓塞前后不同时间段行CT平扫及CT灌注检查,并结合其DSA栓塞结果、临床表现及大脑病理标本综合分析。结果经DSA栓塞并造影证实猴脑一侧大脑中动脉M1分支栓塞成功;于不同时间段行CT灌注扫描,可见相应区域灌注异常,表现为脑血容量及脑血流量降低,造影剂平均通过时间延长;24h后CT平扫亦可见局部低密度梗死灶。结合尸检病理标本,3种检查结果具一致性。结论CT灌注成像能准确判断猴局部脑缺血模型超急性期脑缺血病灶的形成,对临床超急性期脑缺血的早期诊断提供了一种准确、经济及简便的检查方法,特别对指导临床溶栓治疗具有实际应用价值。
Objective To explore the significance of CT perfusion imaging in the study of hyperacute ischemic cerebral infarction (MCAO) by using the monkey local cerebral ischemia model. Methods Autologous white blood clots were obtained from venous blood of Rhesus macaques and were transplanted into the segment of the middle cerebral artery by DSA. CT scan and CT perfusion were performed at different time points before and after embolization. Combined with DSA embolization results, Performance and comprehensive analysis of brain pathology specimens. Results The DSA embolization and angiography proved that the embolization of the M1 artery on the side of the middle cerebral artery in the monkey brain was successful. CT perfusion scanning at different time points showed that the perfusion of the corresponding area was abnormal, showing decreased cerebral blood volume and cerebral blood flow, Extended; CT scan after 24h also showed local low-density infarction. Combined with autopsy pathological specimens, three kinds of test results are consistent. Conclusion CT perfusion imaging can accurately determine the hyperacute ischemic foci in the monkey model of focal cerebral ischemia and provide an accurate, economical and convenient method for the early diagnosis of hyperacute cerebral ischemia in clinical practice, especially for the guidance Clinical thrombolytic therapy has practical value.