论文部分内容阅读
由2-(4’-羧基苯基)咪唑-4,5-二羧酸(HCPhIDC,C12H8N2O6,H4L)和稀土硝酸盐合成了两个稀土配合物[Ln(HCPhIDC)(H2O)2]·3H2O(Ln=Gd(1),Dy(2)),通过元素分析、红外光谱对其进行表征,用单晶X射线衍射方法测定了配合物的晶体结构。结构分析表明:两种晶体属于异质同晶型,同属于三斜晶系,空间群为P1,具有(3,6)-双节点的二维(43)(46·66·83)拓扑结构。测定了配体和配合物与EBDNA体系的作用,结果表明:配体本身对DNA的插入作用很强,而在与稀土离子形成配合物以后,其插入作用反而减弱,这是由于配体本身的分子结构具有良好的平面性,可以很好地插入到DNA的双螺旋结构中,当形成配合物后,整个分子的平面性反而降低了,从而导致插入作用减弱,因此猝灭常数大大降低。
Two rare earth complexes [Ln (HCPhIDC) (H2O) 2] · 3H2O were synthesized from 2- (4’-carboxyphenyl) imidazole-4,5-dicarboxylic acid (HCPhIDC, C12H8N2O6, H4L) and rare earth nitrate (Ln = Gd (1), Dy (2)) were synthesized and characterized by elemental analysis and IR. The crystal structure of the complex was determined by single crystal X-ray diffraction. The structural analysis shows that the two crystals are heterogeneous isomorphic and belong to the triclinic system with P1 (space group) and (43) (46.66.83) topologies with (3,6) - double nodes . The effect of the ligands and complexes on the EBDNA system was determined. The results showed that the ligand itself has a strong insertion effect on DNA, whereas the insertion of the ligand into the EBDNA system is weakened due to the ligand itself The molecular structure has good planarity and can be well inserted into the DNA double helix structure. When the complex is formed, the planarity of the entire molecule is rather reduced, leading to a weakened insertion effect and a drastic reduction of the quenching constant.