子宫内膜异位症是育龄妇女的常见病、多发病,发病率约4％～17％,且本病有30％～40％的患者发生不孕,其不孕的发生机理不清楚。有学者提出细胞因子与子宫内膜异位症不孕发生有着密切的关系,但缺乏明确的认识,而肿瘤坏死因子(TNF)是由激活的免疫细胞产生的具有多重生物学效应的细胞因子,有重要的免疫调控机能。为此我们检测异位症不孕患者腹腔液及巨噬细胞培养上清液中TNF和腹腔淋巴细胞转化率,探讨TNF在子宫内膜异位症不孕免疫发病 Endometriosis is a common disease of women of childbearing age, frequently-occurring disease, the incidence of about 4% to 17%, and the disease has 30% to 40% of patients with infertility, its infertility mechanism is not clear. Some scholars have suggested that cytokines and endometriosis infertility have a close relationship, but the lack of a clear understanding of tumor necrosis factor (TNF) is activated by immune cells with multiple biological effects of cytokines, There is an important immune regulatory function. To this end, we examined the TNF and peritoneal lymphocyte transformation rate in peritoneal fluid and macrophage cell culture supernatant of infertile patients with ectopic endometriosis, to explore the TNF in the pathogenesis of endometriosis infertility