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目的应用主成分Logistic回归探讨2型糖尿病的影响因素。方法采用病例对照研究设计,选择2012年——2013年间首次诊断为2型糖尿病的住院病人109例为病例组,而同期的非糖尿病住院病人122例作为对照组,应用t检验、线性相关与回归(共线性诊断)、主成分分析、非条件二分类Logistic回归,对两组间的生化代谢指标进行统计分析,P<0.05为差异有统计学意义。结果对对照组和病例组的Na+、Cl-、Cr、UA、GLB、DBIL、IBIL、TG、CH、LDL-C、apo A、apo B的含量[(139.55±3.02)、(136.18±5.48)、(103.88±3.70)、(99.30±6.90)mmol/L、(64.96±24.75)、(76.30±52.13)、(353.70±112.39)、(400.38±174.42)μmol/L、(26.87±4.10)、(29.41±4.93)mmol/L、(5.38±5.62)、(3.74±4.35)、(10.74±6.30)μmol/L、(1.64±1.22)、(4.69±5.91)、(4.98±1.15)、(5.47±1.95)、(3.14±0.98)、(3.77±1.91)mmol/L、(1.35±0.34)、(1.22±0.45)、(1.00±0.28)、(1.38±1.11)g/L]差异有统计学意义(P<0.05)。Logistic回归分析显示,Na+、Cl-、Cr、UA、GLB、DBIL、IBIL、TG、CH、LDL-C、apo B等因素与2型糖尿病有关联。结论 Cr、UA、GLB、TG、CH、LDL-C、apo B是2型糖尿病患者的危险因素,建议采取改善不合理饮食、加强体育锻炼和增强体质来降低危险因素水平。
Objective To investigate the influencing factors of type 2 diabetes using principal component Logistic regression. Methods A case-control study was designed. 109 inpatients with type 2 diabetes mellitus diagnosed for the first time between 2012 and 2013 were selected as the case group. 122 non-diabetic inpatients were enrolled in the same period. T-test, linear correlation and regression (Common linear diagnosis), principal component analysis, non-conditional binary Logistic regression analysis of the two groups of biochemical metabolic indicators for statistical analysis, P <0.05 for the difference was statistically significant. Results The contents of Na +, Cl-, Cr, UA, GLB, DBIL, IBIL, TG, CH, LDL-C, apo A and apo B in the control group and the case group [(139.55 ± 3.02), (136.18 ± 5.48) , (103.88 ± 3.70), (99.30 ± 6.90) mmol / L, (64.96 ± 24.75), (76.30 ± 52.13), (353.70 ± 112.39), (400.38 ± 174.42) μmol / L, 29.41 ± 4.93 mmol / L, 5.38 ± 5.62, 3.74 ± 4.35, 10.74 ± 6.30 μmol / L, 1.64 ± 1.22, 4.69 ± 5.91, 4.98 ± 1.15, 1.95 ± 0.34), (1.22 ± 0.45), (1.00 ± 0.28), (1.38 ± 1.11) g / L, respectively, with statistical significance (P <0.05). Logistic regression analysis showed that factors such as Na +, Cl-, Cr, UA, GLB, DBIL, IBIL, TG, CH, LDL-C and apo B were associated with type 2 diabetes. Conclusions Cr, UA, GLB, TG, CH, LDL-C and apo B are the risk factors of type 2 diabetes. It is suggested that the improvement of unreasonable diet, physical exercise and physical fitness should be taken to reduce the risk factors.