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目的了解肠球菌属在临床标本中的分布特点及对抗菌药物的耐药性,为临床合理使用抗菌药物提供参考。方法对医院2010-2014年临床送检的各种标本进行培养,采用VITEK-2Compact全自动微生物分析仪对分离出的1 937株肠球菌属进行鉴定,药敏分析采用VITEK-AMS系统药敏卡及K-B法;采用WHONET5.6软件对结果进行统计分析。结果在1 937株肠球菌属中,屎肠球菌1 091株占56.3%、粪肠球菌672株34.7%;屎肠球菌和粪肠球菌均以泌尿系感染最高,分别占59.9%和53.1%;2010-2014年粪肠球菌对抗菌药物的耐药率远低于屎肠球菌;除屎肠球菌及粪肠球菌对利奈唑胺耐药率较低外,屎肠球菌与粪肠球菌对万古霉素、替考拉宁的耐药率上升速度较快,由2010-2013年的1.4%、0.2%与2.2%、0.3%上升至2014年的7.3%、11.5%与4.9%、8.0%;2010-2014年屎肠球菌对青霉素、氨苄西林年之间相比变化不大,耐药率在85.0%~90.0%,明显高于粪肠球菌的9.0%~25.0%。结论肠球菌属在泌尿系感染中占重要位置;屎肠球菌耐药率明显高于粪肠球菌,应加强对耐药菌株的监测和预防控制。
Objective To understand the distribution characteristics of Enterococcus in clinical specimens and its resistance to antibacterials and provide a reference for the rational use of antibacterials in clinic. Methods A total of 1 937 Enterococcus isolates were identified by VITEK-2 Compact automatic microbial analyzer from 2010 to 2014 in our hospital. Drug susceptibility analysis was performed using VITEK-AMS system And KB method; using WHONET5.6 software for statistical analysis of the results. Results Among 1 937 enterococci, 1 091 strains of Enterococcus faecium accounted for 56.3%, and 672 strains of Enterococcus faecalis accounted for 34.7%. Enterococcus faecalis and Enterococcus faecalis were the highest urinary tract infections, accounting for 59.9% and 53.1% respectively. Enterococcus faecalis in 2010-2014 resistance rate of antibacterials was far lower than Enterococcus faecium; Enterococcus faecium and Enterococcus faecalis resistant to linezolid at a lower rate, Enterococcus faecium and Enterococcus faecium Vancomycin The prevalence of teicoplanin increased rapidly from 1.4%, 0.2% and 2.2% in 2010-2013 to 0.3% in 2014, up from 7.3%, 11.5% and 4.9% and 8.0% in 2014; In 2014, Enterococcus faecium did not change much with respect to penicillin and ampicillin, and the resistance rate was 85.0% -90.0%, significantly higher than that of Enterococcus faecalis by 9.0% -25.0%. Conclusion Enterococcus plays an important role in the urinary tract infection. The resistant rate of Enterococcus faecium is obviously higher than that of Enterococcus faecalis. The surveillance and prevention and control of resistant strains should be strengthened.