人们普遍认为成年的中枢神经不能再生 [1 ,2 ]的原因 ,和胶质疤痕的空间阻碍作用、促神经生长因子的缺乏及髓鞘抑制因子的存在有关 [3 -5 ]。这些抑制因子包括 :蛋白多糖 [6] ,髓鞘相关的糖蛋白 [3 ,5 ]以及牛脑中被称为 Nogo的两种蛋白[7-9] 。我们用牛的相关序列获得了人 Nog It is generally accepted that adult CNS can not regenerate [1, 2], which is related to the steric hindrance of glial scar, the absence of nerve growth factor and the existence of myelin inhibitory factor [3-5]. These inhibitors include proteoglycans [6], myelin-associated glycoproteins [3, 5] and two proteins called Nogo in bovine brain [7-9]. We obtained human Nog using the relevant sequences of cattle