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目的研究 CC16基因多态性与特应症遗传易感性之间的关系。方法应用聚合酶链式反应 (PCR)和限制性片段长度多态性 (RFL P)方法 ,观察了 42个特应症核心家系 (n=135 )中 CC16基因 38A/ G多态性的遗传分布情况 ,并用基于单体型的单体型相对风险关联 (HHRR)和传递不平衡检验 (TDT)进行关联和连锁分析。结果 HHRR关联分析显示等位基因 38A与粉尘过敏 ,高 s Ig E显著关联 (P分别 <0 .0 1,0 .0 5 ) ,TDT结果显示等位基因 38A更多地传递给粉尘过敏患者 (P<0 .0 0 5 )。结论CC16基因多态性可能在特应症遗传机制中起一定作用。
Objective To study the relationship between CC16 gene polymorphism and genetic susceptibility to atopy. Methods The genetic distribution of the 38A / G polymorphism of CC16 gene in 42 atopic families (n = 135) was investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) Cases, and haplotype haplotype-based relative risk association (HHRR) and transmission disequilibrium test (TDT) for association and linkage analysis. Results HHRR correlation analysis showed that allele 38A was significantly associated with dust allergy and high s Ig E (P <0.010,0.0,0.0, respectively). TDT showed that allele 38A was more transmitted to patients with dust allergy P <0 0 05). Conclusion CC16 gene polymorphism may play a role in the genetic mechanism of atopy.