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趋化性细胞因子是一类重要的免疫调节因子 ,为介绍有关趋化性细胞因子 /趋化性细胞因子受体在抗肿瘤免疫反应和自身免疫性疾病中所起的重要作用 ,以及特异性趋化性细胞因子受体阻断剂的应用研究新进展。趋化性细胞因子与趋化性细胞因子受体的相互作用是IL 12诱导的抗肿瘤T细胞向肿瘤局部浸润的必备因素之一 ,当运用CCR5的特异性阻断剂TAK 779时 ,几乎完全阻断了IL 12的抗肿瘤作用 ;在II型胶原蛋白诱导的小鼠关节炎模型上 ,体内给予CCR5的阻断剂TAK 779后 ,关节炎的发病率明显降低 ,临床症状得到显著改善 ;在动物实验中 ,运用抗CCR5的抗体或CXCR3配体Mig的中和抗体可缓解移植物抗宿主反应 (GVHD) ;此外 ,CCR5和CXCR4在HIV感染宿主细胞时是必需的。所以针对趋化性细胞因子及受体的应用研究将为许多疾病的药物治疗提供新的手段
Chemotactic cytokines are a class of important immunomodulatory factors that shed light on the important role of chemokine / chemokine receptor for anti-tumor immune responses and autoimmune diseases, as well as specific Progress in the Research of Chemotactic Cytokine Receptor Blockers. The interaction of chemotactic cytokines with chemotactic cytokine receptors is one of the necessary factors for IL-12-induced local infiltration of antitumor T cells into tumors. When TAK 779, a specific inhibitor of CCR5, is used, almost Completely blocked the antitumor effect of IL 12; in type II collagen-induced mouse arthritis model, the incidence of arthritis was significantly reduced and the clinical symptoms were significantly improved after in vivo administration of CCR5 blocker TAK 779; In animal experiments, neutralizing antibodies against CCR5 or Mig, a ligand for CXCR3, can relieve graft versus host disease (GVHD); in addition, CCR5 and CXCR4 are required for HIV to infect host cells. Therefore, the application of chemotactic cytokines and receptors research will provide new means for the treatment of many diseases