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为探讨三氟拉嗪抗肝纤维化作用的机制，采用链酶蛋白酶、胶原酶及密度梯度离心的方法，分离大鼠肝脏贮脂细胞，用ＭＴＴ方法，观察了三氟拉嗪对贮脂细胞增殖的调控。结果显示低浓度三氟拉嗪的抑制作用不明显（Ｐ＞０．０５），当药物浓度上升为１０～２０μｍｏｌ．Ｌ－１时，抑制作用增强，呈明显药物浓度依赖关系。三氟拉嗪抗肝纤维化的作用是抑制了贮脂细胞的增殖
To investigate the mechanism of anti-liver fibrosis of trifluoperazine, streptolysin, collagenase and density gradient centrifugation were used to separate rat liver fat-storing cells. MTT assay was used to observe the effect of trifluoperazine on lipid- Regulation of proliferation. The results showed that low concentration of trifluoperazine inhibition was not significant (P> 0.05), when the drug concentration increased to 10 ~ 20μmol. L-1, the inhibition increased, showing a clear drug concentration-dependent relationship. The effect of trifluoperazine on hepatic fibrosis is to inhibit the proliferation of lipid-storing cells