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目的探讨性别差异对慢性稳定性冠心病(CHD)合并2型糖尿病(T2DM)患者临床危险因素的影响。方法慢性稳定性CHD合并T2DM患者525例分为女性组(A组,266例)、男性组(B组,259例),其中完成6个月随访的223例分为女性组(A1组,110例)和男性组(B1组,113例)。分析各组一般临床资料及生化指标、左室射血分数和治疗用药情况等。结果与B组相比,A组平均年龄、总胆固醇(TC)均升高(P<0.01),血清肌酐(SCr)和吸烟比例均降低(P<0.01)。6个月随访,与基线值相比,A1、B1组TC、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)均降低(P<0.05),而空腹血糖(FBG)、SCr显著升高(P<0.01);与B1组相比,A1组TC、TG升高(P<0.05),SCr则显著降低(P<0.01)。结论性别差异对慢性稳定性CHD合并T2DM患者的临床危险因素存在影响。
Objective To investigate the influence of gender differences on clinical risk factors in patients with chronic stable coronary heart disease (CHD) complicated with type 2 diabetes mellitus (T2DM). Methods A total of 525 CHD patients with T2DM were divided into female group (A group, 266 cases) and male group (B group, 259 cases), of which 223 cases were divided into female group (A1 group, 110 Cases) and male group (group B1, 113 cases). Analysis of the general clinical data and biochemical indicators of each group, left ventricular ejection fraction and treatment medication situation. Results Compared with group B, the mean age, total cholesterol (TC), serum creatinine (SCr) and smoking in both groups were significantly decreased (P <0.01). After 6 months of follow-up, TC, triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) were lower in A1 and B1 groups than those in baseline (P <0.01). Compared with B1 group, TC and TG increased (P <0.05) and SCr decreased (P <0.01) in A1 group. Conclusion The gender differences affect the clinical risk factors of patients with chronic stable CHD and T2DM.