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目的 探讨组织蛋白酶D(Cath D)在喉鳞癌淋巴转移中与血管内皮生长因子 (VEGF)的关系。方法 通过免疫组化SP法对 6 0例喉癌标本中VEGF、Cath D进行了检测。结果 喉鳞癌中VEGF、Cath D的阳性表达率分别为83%、6 6 %。VEGF表达与Cath D表达相关 (P <0 .0 5 )。在有淋巴结转移的喉癌标本中VEGF、Cath D阳性表达率明显高于非转移组 (P <0 .0 5 )。结论 VEGF、Cath D是喉癌淋巴结转移的重要生物学指标 ,VEGF和Cath D具有协同作用。
Objective To investigate the relationship between cathepsin D (Cath D) and vascular endothelial growth factor (VEGF) in lymph node metastasis of laryngeal squamous cell carcinoma. Methods Immunohistochemical SP method was used to detect VEGF, Cath D in 60 specimens of laryngeal cancer. Results The positive rates of VEGF and Cath D in laryngeal squamous cell carcinoma were 83% and 66%, respectively. VEGF expression was correlated with Cath D expression (P <0.05). The positive rate of VEGF and Cath D in laryngeal carcinoma with lymph node metastasis was significantly higher than that in non-metastatic laryngeal carcinoma (P <0.05). Conclusions VEGF and Cath D are important biological markers of lymph node metastasis in laryngeal cancer. VEGF and Cath D have a synergistic effect.