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肝内胆管细胞癌(ICC)起源于二级胆管及其分支上皮细胞,是恶性程度较高和预后较差的肝脏恶性肿瘤之一。淋巴结转移是严重影响ICC患者预后的因素。近年来,许多研究发现乙型肝炎病毒(HBV)是ICC发生的危险因素之一,HBV相关ICC具有类似与肝细胞癌的临床病理表现。另外,新近研究表明HBV阳性ICC患者术后预后优于HBV阴性患者,且HBV阳性ICC患者淋巴结转移率较低。因此,进一步探索HBV在ICC的发生和预后中的作用有着重要的临床意义。
Intrahepatic cholangiocarcinoma (ICC) originated in the secondary bile duct and its branch epithelial cells, which is one of the malignant tumors with higher malignancy and poorer prognosis. Lymph node metastasis is a serious factor affecting the prognosis of patients with ICC. In recent years, many studies have found that hepatitis B virus (HBV) is one of the risk factors for ICC. HBV-related ICC has similar clinicopathological manifestations to hepatocellular carcinoma. In addition, recent studies have shown that postoperative prognosis of HBV-positive ICC patients is better than that of HBV-negative patients, and HBV-positive ICC patients have lower lymph node metastasis rate. Therefore, to further explore the role of HBV in the occurrence and prognosis of ICC has important clinical significance.