论文部分内容阅读
目的:探讨凯西莱与甘利欣治疗抗结核药物性肝病的临床效果。方法:选取我院2012年3月-2014年7月72例抗结核药物性肝病患者,数字抽取分为凯西莱组(应用凯西莱治疗)与甘利欣组(应用甘利欣治疗),每组36例,分析对比两组患者治疗前与治疗后1周、2周时血清丙氨酸转氨酶(ALT)、门冬酸转氨酶(AST)、血清白蛋白(ALB)、白/球蛋白(A/G)等水平变化。结果:凯西莱组与甘利欣组患者治疗前各个指标对比,差异无统计学意义(P>0.05);治疗后两组患者在第1、2周时ALT、AST对比,差异无统计学意义(P>0.05);凯西莱组治疗后第2周ALB为(46.5±3.8)g/L明显高于甘利欣组(40.2±4.1)g/L,组间比较,差异具有统计学意义(P<0.05);凯西莱组治疗后第1周A/G为(1.6±0.3)高于甘利欣组(1.4±0.3),第2周凯西莱组为(1.9±0.3)明显高于甘利欣组(1.5±0.3),组间比较,差异具有统计学意义(P<0.05)。治疗2周后,凯西莱组总有效率94.44%高于甘利欣组总有效率91.67%,组间比较,差异无统计学意义(P>0.05)。结论:凯西莱、甘利欣对与改善抗结核药物性肝功能损伤均具有较为明显效果,但凯西莱效果更为显著。
Objective: To explore the clinical effect of Kesilai and Glycyrrhizin in the treatment of anti-tuberculosis drug-induced liver disease. Methods: Seventy-two patients with anti-TB drug-induced liver disease were selected from March 2012 to July 2014 in our hospital. The patients were divided into three groups: cassis group (treated with Cassiilac) and Glycyrrhiza group (N = 36). The levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), serum albumin (ALB) and white / globulin / G) and other level changes. Results: There was no significant difference between the two groups before and after treatment (P> 0.05). There was no significant difference in ALT and AST between the two groups after treatment (46.5 ± 3.8) g / L in Kesilai group was significantly higher than that of Glycyrrhiza group (40.2 ± 4.1) g / L in the second week after treatment (P> 0.05). There was significant difference between the two groups P <0.05). The A / G in the Cassis group was (1.6 ± 0.3) higher than that in the Glycyrrhiza group (1.4 ± 0.3) in the first week after treatment, and (1.9 ± 0.3) Group (1.5 ± 0.3), the difference between groups was statistically significant (P <0.05). After 2 weeks of treatment, the total effective rate was 94.44% in Caseile group and 91.67% in Glycyrrhiza group. There was no significant difference between the two groups (P> 0.05). Conclusion: Kesilai and Glycyrrhizin have significant effects on the improvement of hepatic injury induced by anti-TB drugs, but Kesilai is more effective.