患者,女,45岁。因“全身软弱无力、非凹陷性水肿5年,加重伴心前区憋闷1日”于1999年3月16日入院。患者5年前无明显诱因渐出现全身软弱、无力,同时伴全身皮肤粗糙、畏寒、少汗、痴呆、纳差、便秘。入院查表情淡漠、少言懒语、行动迟缓、语言不利,全身皮肤粗糙、伴鳞屑、头发脱落 Patient, female, 45 years old. Due to “weakness of the body, non-pitting edema for 5 years, aggravated with precordial oppressed on the 1st” was admitted on March 16, 1999. 5 years ago, no obvious incentive to gradually appear systemic weakness, weakness, accompanied by rough skin, chills, sweat, dementia, anorexia, constipation. Admission check look indifferent, less lazy words, slow, language disadvantageous, rough skin, with scales, hair loss