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应用生物分型、耐药性谱模式分型和质粒分析，对某医院１９９２年７月份发生的８例阴沟肠杆菌引起的输液反应进行了流行病学调查，结果发现：生物分型和耐药性谱模式分型均不能分辨这８株阴沟肠杆菌的不同克隆菌株，而质粒分析却能对这８株阴沟肠杆菌分辨出４个不同的克隆菌株，显示了它特异和敏感的特性。结合临床资料还发现，这８例阴沟肠杆菌引起的输液反应并非来自同一污染源，各科室存在各自的污染源。半年后的重复试验表明，这８株细菌的生物型和耐药性谱模式分型均有所改变，而它们的质粒图谱却基本保持一致，显示了质粒分析稳定的特性。
Application of genotyping, drug resistance spectrum typing and plasmid analysis of a hospital in July 1992 8 cases of Enterobacter cloacae-induced infusion reaction epidemiological survey found that: the biological typing and drug resistance However, none of the eight genotypes of E. cloacae could be distinguished by sex pattern typing. However, four different clonal isolates were identified from the eight strains of Enterobacter cloacae by plasmid analysis, showing its specificity and sensitivity. Combined with clinical data also found that 8 cases of Enterobacter cloacae infusion reaction does not come from the same source of pollution, each department has its own source of pollution. Repeated tests after six months showed that the pattern of biotype and drug resistance spectrum of the eight strains changed, and their plasmid maps were basically the same, which showed the stable character of plasmid analysis.