气道重构是慢性哮喘的病理改变之一,涉及肺细胞外基质(ECM)沉积和降解失平衡。主要表现为ECM的沉积、基底膜增厚、气道平滑肌增生和肥厚等改变。基质金属蛋白酶(MMPs)通过影响ECM在气道重构中起重要作用。MMPs是一类依赖金属离子锌、钙,并以细胞外基质和基底膜为水解底物的蛋白 Airway remodeling is one of the pathological changes in chronic asthma and involves the deposition and degradation imbalance of pulmonary extracellular matrix (ECM). The main manifestation of ECM deposition, basement membrane thickening, airway smooth muscle proliferation and hypertrophy and other changes. Matrix metalloproteinases (MMPs) play an important role in airway remodeling by affecting ECM. MMPs are a class of proteins that rely on metal ions zinc, calcium, and that hydrolyze substrates with extracellular matrix and basement membrane