CR2主要在成熟B细胞表达,介异B细胞的增殖及EBV的内移。新近发现具有自分泌生长因子作用的B细胞活化抗原CD23能特异与CR2结合,提示CR2具有生长因子受体作用。EBV感染B细胞后导致CR2与CD23同时高水平表达,显示这两个与生长有关的分子参与EBV的转化作用。此外,在口咽、鼻咽、宫颈上皮细胞发现也有CR2的某些表位存在,这种CR2相关分子的生物学意义尚不清楚。 CR2 is mainly expressed in mature B cells, which mediates the proliferation of B cells and the migration of EBV. Recently, it has been found that CD23, a B cell activating antigen with autocrine growth factor, can specifically bind to CR2, suggesting that CR2 has the function of growth factor receptor. Infection of B cells with EBV led to simultaneous high levels of CR2 and CD23 expression, indicating that these two growth-related molecules are involved in the transformation of EBV. In addition, some epitopes of CR2 are also found in oropharyngeal, nasopharyngeal and cervical epithelial cells. The biological significance of this CR2-related molecule is not clear.