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目的探讨分析替普瑞酮联合叶酸治疗萎缩性胃炎的临床疗效。方法 96例萎缩性胃炎患者分为两组,治疗组采用替普瑞酮联合叶酸治疗,对照组仅用叶酸治疗。治疗后,比较两组疗效和不良反应,观察两组治疗前后的各项观察指标变化。结果治疗后,治疗组的总有效率为89.58%,大于对照组的70.83%,具有显著性差异(P<0.05)。治疗组的临床症状积分、胃镜下评分均明显低于对照组,生活质量评分明显高于对照组,均具有显著性差异(P<0.05)。治疗组的不良反应发生率虽略高于对照组,但无显著性差异(P>0.05),且不良反应均较轻微,停药后即缓解或消失。结论替普瑞酮联合叶酸治疗萎缩性胃炎的临床疗效显著,无严重不良反应。
Objective To investigate the clinical efficacy of teprenone combined with folic acid in the treatment of atrophic gastritis. Methods A total of 96 patients with atrophic gastritis were divided into two groups. The treatment group was treated with teprenone and folic acid, while the control group was treated with folic acid only. After treatment, the efficacy and adverse reactions of the two groups were compared, and the changes of various observation indexes before and after treatment were observed. Results After treatment, the total effective rate of the treatment group was 89.58%, which was significantly higher than that of the control group (70.83%) (P <0.05). The scores of clinical symptoms and endoscopy in the treatment group were significantly lower than those in the control group, and the quality of life scores were significantly higher in the treatment group than those in the control group (P <0.05). Although the incidence of adverse reactions in the treatment group was slightly higher than that in the control group, there was no significant difference (P> 0.05). The adverse reactions were mild and relieved or disappeared after treatment. Conclusion Teprenone combined with folic acid treatment of atrophic gastritis significant clinical effect, no serious adverse reactions.